Welcome to iSARST
this service, we implement two protein structural similarity search
Besides, outstanding structural alignment tools, FAST,
are recruited as the refinement engines. The state-of-the-art algorithm
for improving the quality of structure-based sequence alignment SE
is also implemented here. We would like to thank
these authors for their excellent developments, which
have greatly moved this research field forward.
iSARST allows usesr to input many structures at once. Its MPI system
will do the similarity searches and structural alignments in a batch
mode to rapidly retrieve structural homologs of the query proteins.
SARST is designed for co-linear structural similarity search while
CPSARST specifically finds circular permutants.
Circular permutation (CP) of a protein can
be viewed as if the original N- and C-termini were linked and new
ones created elsewhere. CP is more and more widely used in protein
engineering. Please visit CPDB
for detailed information.