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Welcome to iSARST

In this service, we implement two protein structural similarity search methods, SARST and CPSARST. Besides, outstanding structural alignment tools, FAST, TM-align and SAMO, are recruited as the refinement engines. The state-of-the-art algorithm for improving the quality of structure-based sequence alignment SE is also implemented here. We would like to thank these authors for their excellent developments, which have greatly moved this research field forward.

iSARST allows usesr to input many structures at once. Its MPI system will do the similarity searches and structural alignments in a batch mode to rapidly retrieve structural homologs of the query proteins.

SARST is designed for co-linear structural similarity search while CPSARST specifically finds circular permutants.

Circular permutation (CP)
of a protein can be viewed as if the original N- and C-termini were linked and new ones created elsewhere. CP is more and more widely used in protein engineering. Please visit CPDB for detailed information.